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Synapse and Network Development Group

Our group is affiliated with the Department of Neurology at Brigham and Women's Hospital and Harvard Medical School (Boston, Massachusetts, USA) and the Department of Physiology, Development and Neuroscience at the University of Cambridge (Cambridge, England).


Research

Our research focuses on synaptic and network maturation in cortical circuits during early postnatal development and how this process is disrupted in neurodevelopmental disorders including Rett syndrome and autism spectrum disorder (ASD). We have expanded our work with cellular-scale networks from Mecp2-deficient mice to recording network activity from human cerebral organoids. Our ultimate goal is to identify new targets for circuit-based pharmacologic therapies for Rett syndrome and genetic causes of ASD.



News

March 2024
MEA-NAP video tutorial now available on YouTube and the Harvard Dataverse!
David guides new users through the graphical user interface (GUI) for our MEA network analysis pipeline (MEA-NAP)!
You can view at YouTube or download the video at the Harvard Dataverse.

February 2024
MEA-NAP manuscript now available on bioRxiv!
Our manuscript describing our MEA network analysis pipeline (MEA-NAP) is now available
on bioRxiv! Download the manuscript at https://doi.org/10.1101/2024.02.05.578738.

January 2024
Postdoctoral fellowship positions available in SAND!
We have exciting plans for characterizing brain network dynamics and computational performance in
human cerebral organoids from ASD patient-derived iPSCs and isogenic controls! Postdoctoral fellows
with experience in human iPSC-derived neuronal cultures, electrophsyiology, and/or computational
neuroscience should contact Susanna about opportunities in SAND.

December 2023
Alex successfully defended his PhD! Hurrah! He is now a postdoctoral fellow at the MRC CBU in Cambridge
working with Duncan Astle.

September 2023
Elise successfully defended her MPhil thesis on reservoir computing using human cerebral organoids! Hurrah!
She will continue this research with Petra Vertes and our group this year.

June 2023
Victoria Chamberlain (Brown), Hugo Smith (Cambridge), Jeremi Chabros (Cambridge), Ariana Lulu Lourdes Chavez (Emmanuel)
and Tanisha Soto (Brooke High School) will be joining us at the Brigham and Women's Hospital. Xuelin Wang (Cambridge),
Sara Rehman (Cambridge) will be joining us from the University of Cambridge.
It promises to be a fun summer with both intra- and intermodular network collaborations!

May 2023
We have a poster featuring our celllular-scale network analysis of Mecp2-deficient networks in the murine and human-derived
cortical cultures at the International Society for Autism Research (INSAR) Meeting in Stockholm! The poster session starts
at 5:30pm on Thursday, May 4. Come see us at our poster!

April 2023
Alessio is in the final year of his PhD training. We are delighted that he will join our team working on
cellular-scale network development in human-derived neurons for 5-6 months!

January 2023
We are delighted that Dr. Nazanin Ershadinia is joining us as a postdoctoral research associate at the Brigham
and Women's Hospital to work on an exciting collaboration with our Danish and French collaborators!

October 2022
Xuelin Wang has returned to Cambridge to start her Part II Psychology, Neuroscience and Behavior undergraduate
thesis research with us!. Tunyang Xie is joining us for his Part III Systems Biology master's thesis research!
Tunyang will be co-supervised by Bianca Dumitrascu in Computer Science. Both students will join our network
dynamics collaboration.

July 2022
Our MEA network analysis pipeline (MEA-NAP) is ready for its beta release! The code is available
for download on our SAND Github page and the guide for using the pipeline is available on the web or
for download. Susanna will present the pipeline at the MEA Meeting in Tubingen (Germany) on July 7
and Tim, Alex, Yin and Susanna will present the pipeline in the first poster session at the
Federation of European Neuroscience Societies (FENS) Forum in Paris (France) on
Sunday, July 10, 9:30am-1:30pm, Poster S01-128. Come see us at our poster!

June 2022
Xuelin Wang joins us in Boston for the summer. She is an undergraduate in the natural sciences at the
University of Cambridge. Morgan Ellis is an undergraduate at Spelman College in Atlanta studying English
and preparing for a career in medicine. Janani Ganesh will also join us in July. David Oluigbo has joined
an exciting collaboration with the ALFA group at MIT CSAIL this summer working on the calcium imaging network
analysis pipeline.

April 2022
Through a grant funded by the Novo Nordisk Foundation, we will be developing new technology
to combine microelecrode array (MEA) recordings with spatial transcriptomics. This is an
exciting collaborative project with the groups of Vanessa Jane Hall (U of Copenhagen), Martin
Hemberg (BWH), and Yannick Coffinier (U of Lille). This project is based in our group at the Brigham
and Women's Hospital in Boston, MA (USA).

December 2021
Mona is a MPhil student in the Basic and Translational Neuroscience at the University of Cambridge.
She will be joining us in January to work with Yin and Alex on learning to grow, record, and analyse
developing neuronal networks. David is a freshman at MIT in Course 6-9 (computer science and neuroscience)
who will joing our SAND Boston lab in January to learn about growing, recording from and analysing human-derived
developing neuronal networks. He may also join our collaboration with the ALFA group at MIT CSAIL.

October 2021
New FTD-ALS human cerebral organoid model published in Nature Neuroscience! We were very pleased to
contribute to the electrophysiological characterization of the neuronal activity in this new disease model.
See the article at Nature neuroscience or our department's press release.

July 2021
We want to congratulate all of the Part II students on completing your undergraduate degrees!
Congrats Estiaan, Hugo, Jeremi, Lance, Leo and Lucy! Best wishes in the next stage of your clinical training.