For my PhD, I studied the development of cellular-scale brain networks in vitro. I grew primary murine neuronal cultures and record spontaneous activity on microelectrode arrays (MEAs). I also analysed MEA recordings of stem-cell-derived human tissue including cerebral organoid slices. I'm interested in network formation, topology and dynamics and currently focus mainly on graph theoretical metrics and generative models.

As part of my PhD, I investigated how networks containing Mecp2-deficient neurons are disrupted. This may have translational implications as Mecp2 mutations cause most cases of Rett Syndtome. Using optognetic manipulation, I am also lookd at the role of inhibitory neocortical interneurons in these networks as pathology in these cells is heavily linked to Rett Syndrome.